PMR studies of the self-association of DNA intercalating ellipticine derivatives in aqueous solution.
Identifieur interne : 002B03 ( Ncbi/Merge ); précédent : 002B02; suivant : 002B04PMR studies of the self-association of DNA intercalating ellipticine derivatives in aqueous solution.
Auteurs : A. Delbarre ; B P Roques ; J B Le Pecq ; J Y Lallemand ; Nguyen-Dat-XuongSource :
- Biophysical chemistry [ 0301-4622 ] ; 1976.
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Abstract
In aqueous solution DNA intercalating ellipticine derivatives aggregate in n-mers. The self-association constants K are higher than those of 2-methoxy-6-chloro-9-[3-dimethylaminopropyl-amino]-acridine and ethidium bromide. They are of the same order as that of actinomycin D but inferior to that of acridine orange. The increase of the 9-hydroxy-ellipticine constant by addition of sodium chloride shows the importance of anion participation in the mechanism of stacking in accordance with the high energy of self-association. In the stacked n-mers the ellipticine rings are inverted. The geometry shows the importance of the orientation of the quadrupole axis in the intermolecular association of the intercalating drugs.
DOI: 10.1016/0301-4622(76)80075-0
PubMed: 949529
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Delbarre</name></author><author><name sortKey="Roques, B P" sort="Roques, B P" uniqKey="Roques B" first="B P" last="Roques">B P Roques</name></author><author><name sortKey="Le Pecq, J B" sort="Le Pecq, J B" uniqKey="Le Pecq J" first="J B" last="Le Pecq">J B Le Pecq</name></author><author><name sortKey="Lallemand, J Y" sort="Lallemand, J Y" uniqKey="Lallemand J" first="J Y" last="Lallemand">J Y Lallemand</name></author><author><name sortKey="Nguyen Dat Xuong" sort="Nguyen Dat Xuong" uniqKey="Nguyen Dat Xuong" last="Nguyen-Dat-Xuong">Nguyen-Dat-Xuong</name></author></analytic><series><title level="j">Biophysical chemistry</title><idno type="ISSN">0301-4622</idno><imprint><date when="1976" type="published">1976</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alkaloids</term><term>Binding Sites</term><term>Calorimetry</term><term>DNA</term><term>Ellipticines</term><term>Kinetics</term><term>Magnetic Resonance Spectroscopy</term><term>Mathematics</term><term>Molecular Conformation</term><term>Nucleic Acid Conformation</term><term>Structure-Activity Relationship</term><term>Thermodynamics</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ADN</term><term>Alcaloïdes</term><term>Calorimétrie</term><term>Cinétique</term><term>Conformation d'acide nucléique</term><term>Conformation moléculaire</term><term>Ellipticines</term><term>Mathématiques</term><term>Relation structure-activité</term><term>Sites de fixation</term><term>Spectroscopie par résonance magnétique</term><term>Thermodynamique</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Alkaloids</term><term>DNA</term><term>Ellipticines</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Binding Sites</term><term>Calorimetry</term><term>Kinetics</term><term>Magnetic Resonance Spectroscopy</term><term>Mathematics</term><term>Molecular Conformation</term><term>Nucleic Acid Conformation</term><term>Structure-Activity Relationship</term><term>Thermodynamics</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>ADN</term><term>Alcaloïdes</term><term>Calorimétrie</term><term>Cinétique</term><term>Conformation d'acide nucléique</term><term>Conformation moléculaire</term><term>Ellipticines</term><term>Mathématiques</term><term>Relation structure-activité</term><term>Sites de fixation</term><term>Spectroscopie par résonance magnétique</term><term>Thermodynamique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In aqueous solution DNA intercalating ellipticine derivatives aggregate in n-mers. The self-association constants K are higher than those of 2-methoxy-6-chloro-9-[3-dimethylaminopropyl-amino]-acridine and ethidium bromide. They are of the same order as that of actinomycin D but inferior to that of acridine orange. The increase of the 9-hydroxy-ellipticine constant by addition of sodium chloride shows the importance of anion participation in the mechanism of stacking in accordance with the high energy of self-association. In the stacked n-mers the ellipticine rings are inverted. The geometry shows the importance of the orientation of the quadrupole axis in the intermolecular association of the intercalating drugs.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">949529</PMID><DateCompleted><Year>1976</Year><Month>10</Month><Day>02</Day></DateCompleted><DateRevised><Year>2019</Year><Month>08</Month><Day>27</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0301-4622</ISSN><JournalIssue CitedMedium="Print"><Volume>4</Volume><Issue>3</Issue><PubDate><Year>1976</Year><Month>May</Month></PubDate></JournalIssue><Title>Biophysical chemistry</Title><ISOAbbreviation>Biophys. Chem.</ISOAbbreviation></Journal><ArticleTitle>PMR studies of the self-association of DNA intercalating ellipticine derivatives in aqueous solution.</ArticleTitle><Pagination><MedlinePgn>275-9</MedlinePgn></Pagination><Abstract><AbstractText>In aqueous solution DNA intercalating ellipticine derivatives aggregate in n-mers. The self-association constants K are higher than those of 2-methoxy-6-chloro-9-[3-dimethylaminopropyl-amino]-acridine and ethidium bromide. They are of the same order as that of actinomycin D but inferior to that of acridine orange. The increase of the 9-hydroxy-ellipticine constant by addition of sodium chloride shows the importance of anion participation in the mechanism of stacking in accordance with the high energy of self-association. In the stacked n-mers the ellipticine rings are inverted. The geometry shows the importance of the orientation of the quadrupole axis in the intermolecular association of the intercalating drugs.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Delbarre</LastName><ForeName>A</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Roques</LastName><ForeName>B P</ForeName><Initials>BP</Initials></Author><Author ValidYN="Y"><LastName>Le Pecq</LastName><ForeName>J B</ForeName><Initials>JB</Initials></Author><Author ValidYN="Y"><LastName>Lallemand</LastName><ForeName>J Y</ForeName><Initials>JY</Initials></Author><Author ValidYN="Y"><LastName>Nguyen-Dat-Xuong</LastName></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Biophys Chem</MedlineTA><NlmUniqueID>0403171</NlmUniqueID><ISSNLinking>0301-4622</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000470">Alkaloids</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D004611">Ellipticines</NameOfSubstance></Chemical><Chemical><RegistryNumber>9007-49-2</RegistryNumber><NameOfSubstance UI="D004247">DNA</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000470" MajorTopicYN="Y">Alkaloids</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001665" MajorTopicYN="N">Binding Sites</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002151" MajorTopicYN="N">Calorimetry</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004247" MajorTopicYN="Y">DNA</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004611" MajorTopicYN="Y">Ellipticines</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007700" MajorTopicYN="N">Kinetics</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009682" MajorTopicYN="N">Magnetic Resonance Spectroscopy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008433" MajorTopicYN="N">Mathematics</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008968" MajorTopicYN="N">Molecular Conformation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009690" MajorTopicYN="N">Nucleic Acid Conformation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013329" MajorTopicYN="N">Structure-Activity Relationship</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013816" MajorTopicYN="N">Thermodynamics</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1976</Year><Month>5</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1976</Year><Month>5</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1976</Year><Month>5</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">949529</ArticleId><ArticleId IdType="pii">0301-4622(76)80075-0</ArticleId><ArticleId IdType="doi">10.1016/0301-4622(76)80075-0</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list></list><tree><noCountry><name sortKey="Delbarre, A" sort="Delbarre, A" uniqKey="Delbarre A" first="A" last="Delbarre">A. Delbarre</name><name sortKey="Lallemand, J Y" sort="Lallemand, J Y" uniqKey="Lallemand J" first="J Y" last="Lallemand">J Y Lallemand</name><name sortKey="Le Pecq, J B" sort="Le Pecq, J B" uniqKey="Le Pecq J" first="J B" last="Le Pecq">J B Le Pecq</name><name sortKey="Nguyen Dat Xuong" sort="Nguyen Dat Xuong" uniqKey="Nguyen Dat Xuong" last="Nguyen-Dat-Xuong">Nguyen-Dat-Xuong</name><name sortKey="Roques, B P" sort="Roques, B P" uniqKey="Roques B" first="B P" last="Roques">B P Roques</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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